Joe called this "The best presentation I've ever seen. Not even close." I don't know if I'll go that far, but I will say that it's very, very good and it reinforces my belief that the best speakers/presenters forego PowerPoint presentations. Also, chalk boards/white boards are two of the most underrated communication tools in the universe. Finally, great presentations almost always result from a combination of genius, preparation, personality and "it" factor. Technology can enhance these elements, but it can't replace them or hide a speakers 

About the presentation itself: I've never, ever seen anyone take complex, medical/scientific information and break it down into layman's terms as well as Sapolsky does here. Phenomenal, and a must watch for anyone with an interest in depression.