You can read Bill Gates' 2010 Annual Letter for the Bil & Melinda Gates Foundation here.  It's broken into 12 sections which you will find below.  Personally I really like the line at the top of every page: "All Lives Have Equal Value"

• Page 1: Introduction

• Page 2: Innovation

• Page 3: Childhood Deaths

• Page 4: The Miracle of Vaccines

• Page 5: Malaria

• Page 6: Polio Eradication

• Page 7: HIV/AIDS

• Page 8: Helping Teachers Improve

• Page 9: Online Learning

• Page 10: Agriculture

• Page 11: Rich Countries' Aid Generosity

• Page 12: Looking Ahead